|AB Science provides the summary of webcast with Key Opinion Leaders on masitinib Phase 3 results in severe asthma uncontrolled by oral corticosteroids|
|By GLOBE NEWSWIRE|
|Monday, 02 December 2019 11:31|
Paris, 02 December 2019, 10.15pm
Summary of webcast with Key Opinion Leaders on masitinib
AB Science SA (NYSE Euronext - FR0010557264 - AB) is providing a summary of the live webcast held on 02 December with key opinion leaders on severe asthma uncontrolled by oral corticosteroids (OCS) and the role that masitinib may play in treating this disorder.
The presentation of the webcast is available on the company’s website.
Masitinib is a first in class oral drug in severe asthma, selectively targeting mast cells. There is a strong scientific rationale to target mast cells in asthma and study AB07015 was the first positive large-scale study in severe asthma utilizing a drug targeting mast cells.
Study AB07015 demonstrated efficacy in a difficult to treat population, with 100% of patients receiving high dose (OCS) maintenance therapy, but not required to have high blood eosinophil levels. Results demonstrating masitinib’s reduction of severe asthma exacerbations were consistent and robust.
The clinical data are encouraging and we are optimistic about the future development of masitinib in severe asthma.
The masitinib safety profile was acceptable based on available data. The occurrence of adverse events (AEs) and serious adverse events (SAEs) was comparable between masitinib and placebo.
Masitinib is uniquely positioned in severe asthma with respect to administration (oral administration), mechanism of action, an identified target population, concomitant use of OCS, and eosinophil counts in the studied population.
There is still a need for alternative therapies in asthma despite the progress achieved in recent years. Masitinib has several strategic positioning opportunities in severe asthma that are complementary to biologics utilization. Masitinib could potentially be positioned in the following indications:
The following key opinion leaders participated in the webcast:
Pascal CHANEZ, MD, PhD: Dr. Pascal Chanez is Professor of Respiratory Medicine at the APHM and Aix Marseille University at Marseille France. He coordinates a research group at INSERM-CNRS - Aix Marseille University CV2N Center on the role of bronchial epithelium in inflammation and environmental aggression in severe bronchial diseases. He is the head of a clinical research group investigating new innovative treatments for severe asthma and COPD. He is the author or co-author of more than 300 peer reviewed articles, reviews and monographs. He was an editor of the European Respiratory Journal and is an editor of the Journal of allergy and clinical Immunology. His clinical and research interests are devoted to a better understanding of the mechanisms of severe asthma and COPD with a special focus on combining clinical and biological findings to identify new specific biomarkers and therapies.
Lavinia DAVIDESCU, MD, PhD: Dr. Lavinia Davidescu is Assistant Professor at the Faculty of Medicine and Pharmacy, University of Oradea. She is president of the Rare Disease Section of Romanian Pneumology Society, member in the boarding Committee of the Romanian Society of Pneumology. She is the coordinating investigator of masitinib study AB07015 in severe asthma uncontrolled with oral corticosteroids.
Elliot ISRAEL, MD: Dr. Elliot Israel is the director of clinical research in the Pulmonary and Critical Care Medicine Division and an associate physician at Brigham and Women’s Hospital (BWH). He is also a professor of medicine at Harvard Medical School. Dr. Israel’s research interests include therapeutic interventions to alter asthmatic airway hyperactivity and the role of arachidonic acid metabolites in airway narrowing. He has written over 200 peer-reviewed publications and currently leads a team researching novel asthma treatments funded by the National Institutes of Health. He is the recipient of the HMS Daniel D. Federman Outstanding Clinical Educator Award and was named one of “Boston’s best in Pulmonary Medicine” by Boston Magazine.
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