Pfizer, Medivation's phase 3 study for Huntington's disease drug fails Print E-mail
By Deborah Sterescu -   
Monday, 11 April 2011 14:20

Pfizer (NYSE:PFE) and Medivation (NASDAQ:MDVN) announced Monday disappointing results from their phase 3 trial for dimebon, a drug designed to treat patients with Huntington's disease, a disorder in which nerve cells in the brain degenerate.

The drug, known as latrepirdine in its generic form, did not achieve statistical significance  for either of the two main goals of the Horizon study, which measured cognition and global function, the companies said.

"We are disappointed with the results of the HORIZON trial given the high unmet need in this patient population," said president and CEO of Medivation, David Hung.

"At this point, we will discontinue development of dimebon in Huntington disease, including the ongoing open-label extension study."

Medivation and Pfizer did say, however, that they will continue an ongoing 12-month phase 3 study for the drug in patients with mild to moderate Alzheimer's disease, for which results are expected in the first half of 2012.

The phase 3 Horizon trial enrolled 403 patients with Huntington disease at 64 sites in North America, Europe and Australia. Patients were randomized to receive either 20 mg of dimebon three times daily, or placebo, for six months.

The study was conducted under a global collaboration agreement between Pfizer and Medivation to develop and commercialize dimebon for the treatment of Alzheimer's disease and Huntington's disease.

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