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Last month, the company had told investors that it expected to release this statement regarding the result for overall survival in May as data collection process for this double-blind trial had not yet been completed.

AGENDA was a randomized, double-blind, placebo-controlled trial of dacarbazine administered with or without Genasense(R) in patients who had not previously received chemotherapy. As defined in a prior randomized trial, AGENDA employed a biomarker to define patients who might maximally benefit from such treatment.

In the trial, median survival was 13.5 months in the Genasense group(R) and 13.1 months in the chemotherapy-only group (P=0.73). The durable response rate (i.e., the proportion of patients who achieved a major objective response that persists at least 6 months) was 10.8% and 7.6%, respectively (P=0.32).

The safety profile of Genasense in AGENDA was consistent with prior studies, as previously released.

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