Multiple Sclerosis drug hits mid-stage goals Print E-mail
By Staff and Wire Reports   
Tuesday, 09 August 2011 08:27
Biogen Idec (NASDAQ:BIIB) and Abbott (NYSE:ABT) today announced positive top-line results for their experimental once-monthly drug for multiple sclerosis achieved the main goals in a mid-stage trial.

The drug, daclizumab, was injected once every four weeks in the 600-patient Phase IIb study.According to initial results released by the companies, the drug significantly reduced annualized relapse rates by 54 percent for patients on the 150 milligram dose and 50 percent for those on the 300 mg dose compared with those taking a placebo.

The SELECT trial also investigated DAC HYP’s effect on disability progression as measured by the expanded disability status scale (EDSS) as a tertiary endpoint. Findings showed that DAC HYP reduced the risk of sustained disability progression at one year by 57 percent in the 150 mg dose arm and by 43 percent in the 300 mg dose arm compared to placebo. Additional analyses are ongoing and the companies anticipate presenting detailed data at an upcoming medical meeting.

“The exciting results for DAC HYP, along with previous clinical data, support our continued investigation of this candidate as a promising new approach to treating multiple sclerosis,” said Doug Williams, Ph.D., Biogen Idec’s Executive Vice President of Research and Development. “DAC HYP’s convenient once-monthly, subcutaneous administration, combined with a strong efficacy profile, suggest that it may provide an attractive option for MS patients. We hope to confirm the results of SELECT in our second registrational trial, DECIDE.”

“These results bring us one step closer in the development of a potential new treatment option for multiple sclerosis, an area of medicine where there continues to be a significant need for novel approaches for patients," said Eugene Sun, M.D., Vice President, Global Pharmaceutical Clinical Development, Abbott. "We look forward to continued analysis of the SELECT data and the opportunity to present these results in full context at an upcoming scientific forum."

Biogen Idec uses cutting-edge science to discover, develop, manufacture and market therapies for the treatment of serious diseases with a focus on neurological disorders. Founded in 1978, Biogen Idec is the world's oldest independent biotechnology company. Patients worldwide benefit from its leading multiple sclerosis therapies, and the company generates more than $4 billion in annual revenues.




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